Arizona Republican Sen. John McCain, a Vietnam War hero and 2008 candidate for President of the United States, died on Saturday at the age of 81 from the brain cancer he was diagnosed with in 2017.

“Senator John Sidney McCain III died at 4:28pm on August 25, 2018. With the senator when he passed were his wife Cindy and their family,” a statement from his office read. “At his death, he had served the United States of America faithfully for 60 years.”

Coincidentally Sen. McCain died nine years to the day that his close friend, Democrat Sen. Ted Kennedy died from the same rare form of cancer, glioblastoma. The same cancer also took the life of former Vice President Joe Biden’s son Beau.

President Donald Trump tweeted shortly after the news broke, offering his support for the family of the senator with whom he has clashed extensively since he was campaigning for president in 2016.

“My deepest sympathies and respect go out to the family of Senator John McCain. Our hearts and prayers are with you!” the president said on Twitter.

“John McCain and I were members of different generations, came from completely different backgrounds, and competed at the highest level of politics. But we shared, for all our differences, a fidelity to something higher – the ideals for which generations of Americans and immigrants alike have fought, marched, and sacrificed. We saw our political battles, even, as a privilege, something noble, an opportunity to serve as stewards of those high ideals at home, and to advance them around the world. We saw this country as a place where anything is possible – and citizenship as our patriotic obligation to ensure it forever remains that way,” former President Obama said in a statement.

“Few of us have been tested the way John once was, or required to show the kind of courage that he did. But all of us can aspire to the courage to put the greater good above our own. At John’s best, he showed us what that means. And for that, we are all in his debt. Michelle and I send our most heartfelt condolences to Cindy and their family,” he said.

“John McCain believed that every citizen has a responsibility to make something of the freedoms given by our Constitution, and from his heroic service in the Navy to his 35 years in Congress, he lived by his creed every day,” former President Bill Clinton said.

His wife, Cindy McCain, said “My heart is broken. I am so lucky to have lived the adventure of loving this incredible man for 38 years. He passed the way he lived, on his own terms, surrounded by the people he loved, in the place he loved best.”

His daughter Meghan McCain made a statement of her own.

Other tributes poured in from the entire political world.

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